Interleukin-31 is associated with uremic pruritus in patients receiving hemodialysis  

Oleh:

Mei-Ju, Ko ; Yu-Sen, Peng ; Hung-Yuan, Chen ; Shih-Ping, Hsu ; Mei-Fen, Pai

Jenis: Article from Journal - ilmiah internasional
Dalam koleksi: JAAD: Journal of the American Academy of Dermatology (keterangan: ada di ClinicalKey) vol. 71 no. 06 (Dec. 2014), page 1151–1159.
Topik: cytokines; hemodialysis; interleukin-31; itching; pruritogen; uremic pruritus

Ketersediaan

Perpustakaan FK Nomor Panggil: J15.K Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

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Isi artikel

Background Interleukin (IL)-31 induces severe pruritus and dermatitis in transgenic mice, and is associated with many itching skin diseases. Objective We sought to investigate the association of serum IL-31 levels with uremic pruritus in patients undergoing hemodialysis. Methods Patients receiving maintenance hemodialysis in a referral medical center were recruited. Serum IL-31 levels were determined by the enzyme-linked immunosorbent assay methodology. The various characteristics of pruritus were assessed using an interview questionnaire. Results Among the 178 study participants, 34.8% had uremic pruritus. The patients with pruritus had higher serum IL-31 levels than those without pruritus symptoms (median 8.68 [first quartile 0.43, third quartile 35.04] vs 4.91 [0, 15.78], P = .04). A multivariate linear regression analysis showed that higher serum levels of IL-31, high-sensitivity C-reactive protein, and alanine transaminase, and a lower dialysis dose assessed by Kt/V, were independent predictors for higher pruritus intensity. The generalized additive model also showed a positive exposure-response relationship between serum levels of IL-31 and visual analog scale scores of pruritus intensity. Limitations The cause-effect relationship between IL-31 and uremic pruritus could not be assessed by the cross-sectional study design. Conclusion IL-31 may play an important role in the pathophysiology of uremic pruritus.

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