Pruritus: An underrecognized symptom of small-fiber neuropathies  

Oleh:

Brenaut, Emilie ; Marcorelles, Pascale ; Genestet, Steeve ; Menard, Dominique ; Misery, Laurent

Jenis: Article from Journal - ilmiah internasional
Dalam koleksi: JAAD: Journal of the American Academy of Dermatology (keterangan: ada di ClinicalKey) vol. 72 no. 02 (Feb. 2015), page 328–332 .
Topik: pruritus; questionnaire; sensory symptoms; small-fiber neuropathy

Ketersediaan

Perpustakaan FK Nomor Panggil: J15.K Non-tandon: tidak ada Tandon: 1

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Isi artikel

Background Small-fiber neuropathies (SFN) are diseases of small nerve fibers that are characterized by autonomic and sensory symptoms. Objective We sought to evaluate sensory symptoms, especially pruritus, in patients with SFN. Methods A questionnaire was given to patients with SFN. Results In all, 41 patients responded to the questionnaire (71.9% response rate). The most frequent sensory symptoms were burning (77.5%), pain (72.5%), heat sensations (70.2%), and numbness (67.5%). Pruritus was present in 68.3% of patients. It appeared most often in the evening, and was localized to the limbs in a distal-to-proximal gradient, although the back was the most frequent location (64%). Exacerbating factors were fatigue, xerosis, sweating, hot temperature, and stress. Cold water was an alleviating factor. Limitations Recall bias associated with filling out the questionnaire, relatively small sample size, and the uncontrolled, retrospective nature of the study were limitations. Conclusion Pruritus occurs frequently in patients with SFN and could be recognized as a possible presenting symptom, especially if there are other sensory or autonomic symptoms.

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