Treatment of coexistent psoriasis and lupus erythematosus  

Oleh:

Varada, Sowmya ; Gottlieb, Alice B. ; Merola, Joseph F. ; Saraiya, Ami R. ; Tintle, Suzanne J.

Jenis: Article from Journal - ilmiah internasional
Dalam koleksi: JAAD: Journal of the American Academy of Dermatology (keterangan: ada di ClinicalKey) vol. 72 no. 02 (Feb. 2015), page 253–260 .
Topik: psoriasis; lupus erythematosus; tumor necrosis factor alfa

Ketersediaan

Perpustakaan FK Nomor Panggil: J15.K Non-tandon: tidak ada Tandon: 1

Lihat Detail Induk

Isi artikel

Background The coexistence of psoriasis and lupus erythematosus (LE) is rare. Anecdotal evidence suggests that anti–tumor necrosis factor alfa (TNF-a) agents may be efficacious in LE, although their use is commonly avoided in this disease because of concern for lupus flare. Objective We sought to describe the epidemiology, serologic findings, and therapeutic choices in patients with coexistent psoriasis/psoriatic arthritis and LE and to determine the risk of lupus flares with TNF-a inhibitors. Methods We performed a retrospective multicenter study of patients given the diagnoses of psoriasis (or psoriatic arthritis) and lupus erythematosus (systemic LE or cutaneous LE, including either subacute cutaneous LE or discoid LE) at 2 academic tertiary-care centers. Results A total of 96 patients with a mean age of 56 years was included. We report higher-than-expected rates of white race and psoriatic arthritis. One clinical lupus flare was observed in a patient receiving a TNF-a inhibitor, resulting in an incidence of 0.92% lupus flares per patient-year of TNF-a inhibitor use. Limitations Retrospective chart review, small sample size, and limited documentation. Conclusion Anti–TNF-a agents, ustekinumab, and abatacept may be valid treatment options for patients with concomitant LE and psoriasis. Clinical lupus flares in LE patients treated with TNF-a inhibitors were infrequent.

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