Therapeutic management of DRESS: A retrospective study of 38 cases  

Oleh:

Funck-Brentano, Elisa ; Tu-Anh, Duong ; Bouvresse, Sophie ; Bagot, Martine ; Wolkenstein, Pierre

Jenis: Article from Journal - ilmiah internasional
Dalam koleksi: JAAD: Journal of the American Academy of Dermatology (keterangan: ada di ClinicalKey) vol. 72 no. 02 (Feb. 2015), page 246–252 .
Topik: drug-induced hypersensitivity syndrome; drug reaction with eosinophilia and systemic symptoms; severe cutaneous adverse reactions; systemic corticosteroids treatment; therapeutic management; topical steroids

Ketersediaan

Perpustakaan FK Nomor Panggil: J15.K Non-tandon: tidak ada Tandon: 1

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Isi artikel

Background There is no consensus regarding treatment for drug reaction with eosinophilia and systemic symptoms (DRESS). Objectives We report a single-center observational series of therapeutic management of DRESS. Methods We examined data for 50 consecutive patients admitted from March 2005 to June 2009 with a discharge diagnosis of DRESS (RegiSCAR score). Results For the 38 patients with a DRESS score of 4 or more, topical steroid treatment alone was initiated in 66% of cases. On admission, 13 patients received systemic steroids; in 7 of them, systemic steroid treatment was initiated or maintained for life-threatening organ failure, with kidney, lung, and/or nervous system involvement. Complications of DRESS, such as relapse, viral reactivation, and sepsis, were less frequent with topical steroid than with systemic steroids. None of the patients died during their stay in hospital. Limitations Retrospective nonblinded design and dermatologic recruitment are limitations. The variables underlying the choice of treatment study were not analyzed. Conclusions Systemic steroids may not be required for the management of mild forms of DRESS, and may thus be reserved for more severe cases. Prospective studies are required to evaluate strategies for treating DRESS.

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