Older Age Is Associated with Rapid Remission of Depression After Electroconvulsive Therapy: A Latent Class Growth Analysis  

Oleh:

Rhebergen, Didi ; Huisman, Anne ; Bouckaert, Filip ; King, Kho ; Rob, Kok

Jenis: Article from Journal - ilmiah internasional
Dalam koleksi: The American Journal of Geriatric Psychiatry (keterangan: ada di ClinicalKey) vol. 23 no. 03 (Mar. 2015), page 274–282 .
Topik: Depression; ECT; latent class growth analysis; prognosis

Ketersediaan

Perpustakaan FK Nomor Panggil: A35.K Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

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Objectives This study aims to empirically identify latent course trajectories of depressive symptoms during electroconvulsive therapy (ECT) within a cohort of patients suffering from a depressive disorder and to examine putative predictors of course. Methods Using a prospective cohort multicenter collaborative ECT design, 120 patients fulfilling the Mini International Neuropsychiatric Interview criteria for major depressive disorder and referred for ECT were selected. Ratings of the 17-item Hamilton Rating Scale for Depression (HRSD) were obtained weekly during the course of ECT. Latent class growth analysis was used to identify trajectories of course during 6-week follow-up, based on weekly total HRSD scores. Characteristics of the identified classes were examined, and putative predictors for class membership were tested. Results Data-driven techniques identified distinct course trajectories during 6-week follow-up ECT treatment, consisting of “rapid remission,” “moderate response,” and “nonremitting” course trajectories. Remission rates were as high as 80.1% in the rapid remission class. Older age was associated with rapid remission, even after adjustment for putative confounders. Conclusion Our results strongly confirm the favorable outcome of ECT among elderly depressed inpatients.

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