Prospective study into the value of the automated Elecsys antimüllerian hormone assay for the assessment of the ovarian growing follicle pool  

Oleh:

Anderson, Richard A. ; Anckaert, Ellen ; Bosch, Ernesto ; Dewailly, Didier

Jenis: Article from Journal - ilmiah internasional
Dalam koleksi: Fertility and Sterility (keterangan: ada di ClinicalKey) vol. 103 no. 04 (Apr. 2015), page 1074-1080.
Topik: Antimüllerian hormone; antral follicle count; ovarian follicle; ovarian reserve; reproductive life span
Fulltext: PIIS0015028215000394.pdf (996.89KB)

Ketersediaan

Perpustakaan FK Nomor Panggil: F02.K Non-tandon: tidak ada Tandon: 1

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Isi artikel

Objective To evaluate a new fully automated assay measuring antimüllerian hormone (AMH; Roche Elecsys) against antral follicle count in women of reproductive age. Design Prospective cohort study. Setting Hospital infertility clinics and academic centers. Patient(s) Four hundred fifty-one women aged 18 to 44 years, with regular menstrual cycles. Intervention(s) None. Main Outcome Measure(s) AMH and antral follicle count (AFC) determined at a single visit on day 2–4 of the menstrual cycle. Result(s) There was a statistically significant variance in AFC but not in AMH between centers. Both AFC and AMH varied by age (overall Spearman rho -0.50 for AFC and -0.47 for AMH), but there was also significant between-center variation in the relationship between AFC and age but not for AMH. There was a strong positive correlation between AMH and AFC (overall spearman rho 0.68), which varied from 0.49 to 0.87 between centers. An agreement table using AFC cutoffs of 7 and 15 showed classification agreement in 63.2%, 56.9% and 74.5% of women for low, medium, and high groups, respectively. Conclusion(s) The novel fully automated Elecsys AMH assay shows good correlations with age and AFC in women of reproductive age, providing a reproducible measure of the growing follicle pool.

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