Use of gonadotropin-releasing hormone agonist trigger during in vitro fertilization is associated with similar endocrine profiles and oocyte measures in women with and without polycystic ovary syndrome  

Oleh:

O'Neill, Kathleen E. ; Senapati, Suneeta ; Dokras, Anuja

Jenis: Article from Journal - ilmiah internasional
Dalam koleksi: Fertility and Sterility (keterangan: ada di ClinicalKey) vol. 103 no. 01 (Jan. 2015), page 264-269.
Topik: GnRHa trigger; PCOS; IVF outcomes; OHSS
Fulltext: PIIS0015028214022249.pdf (225.25KB)

Ketersediaan

Perpustakaan FK Nomor Panggil: F02.K Non-tandon: tidak ada Tandon: 1

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Isi artikel

Objective To compare endocrine profiles and IVF outcomes after using GnRH agonists (GnRHa) to trigger final oocyte maturation in women with polycystic ovary syndrome (PCOS) with other hyper-responders. Design Retrospective cohort study. Setting Academic center. Patient(s) Forty women with PCOS and 74 hyper-responders without PCOS. Intervention(s) GnRHa trigger. Main Outcome Measure(s) Number of oocytes. Result(s) Serum E2, LH, and P levels on the day of GnRHa trigger and the day after trigger did not differ significantly between groups. There were no significant differences in total number of oocytes or percent mature oocytes obtained between groups after controlling for age, antral follicle count, and total days of stimulation. The overall rate of no retrieval of oocytes after trigger was low (2.6%). Fertilization, implantation, clinical pregnancy, and live-birth rates were similar in the two groups. No patients developed ovarian hyperstimulation syndrome (OHSS). Conclusion(s) The similar post-GnRHa trigger hormone profiles and mature oocyte yield support the routine use of GnRHa trigger to prevent OHSS in women with PCOS.

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