Preconceptional thyroid-stimulating hormone levels and outcomes of intrauterine insemination among euthyroid infertile women  

Oleh:

Karmon, Anatte E. ; Batsis, Maria ; Chavarro, Jorge E. ; Souter, Irene

Jenis: Article from Journal - ilmiah internasional
Dalam koleksi: Fertility and Sterility (keterangan: ada di ClinicalKey) vol. 103 no. 01 (Jan. 2015), page 258-263.
Topik: Thyroid-stimulating hormone; intrauterine insemination; infertility; spontaneous abortion; miscarriage
Fulltext: PIIS0015028214022122.pdf (350.26KB)

Ketersediaan

Perpustakaan FK Nomor Panggil: F02.K Non-tandon: tidak ada Tandon: 1

Lihat Detail Induk

Isi artikel

Objective To evaluate differences in intrauterine insemination (IUI) outcomes among euthyroid women with preconceptional thyroid-stimulating hormone (TSH) values in the normal (0.4–2.4 mIU/L) and high-normal (2.5–4.9 mIU/L) ranges. Design Cohort study. Setting A single fertility center. Patient(s) A total of 1,477 women who underwent 4,064 IUI cycles between the years 2004 and 2012. Intervention(s) None. Main Outcome Measure(s) Live birth, clinical pregnancy, spontaneous abortion (SAB), and IUI cycle parameters. Result(s) Cycles were categorized into 4 groups based on preconceptional TSH values: 0.40–1.36 mIU/L; 1.37–1.86 mIU/L; 1.87–2.49 mIU/L; and 2.50–4.99 mIU/L. No statistically significant differences were found in IUI cycle parameters, clinical pregnancy rates, or live births per initiated cycle among the 4 TSH groups. However, preconceptional TSH was inversely related to SAB and positively related to live birth among women who achieved a clinical pregnancy. In this group of women, cycles with TSH values between 2.5 and 4.9 mIU/L were related to lower odds of SAB (odds ratio: 0.32; 95% confidence interval: 0.16–0.65) and higher odds of live birth (odds ratio: 2.80; 95% confidence interval: 1.43–5.48) compared with cycles among women in the lowest TSH group. Conclusion(s) Among euthyroid patients, preconceptional TSH values in the high-normal range (between 2.5 and 4.9 mIU/L) are not associated with adverse IUI outcomes.

Opini Anda

Klik untuk menuliskan opini Anda tentang koleksi ini!

Kembali