Meta-analysis of estradiol for luteal phase support in in vitro fertilization/intracytoplasmic sperm injection  

Oleh:

Na, Huang ; Bing, Situ ; Xiao Chen ; Jiangqiao, Liu

Jenis: Article from Journal - ilmiah internasional
Dalam koleksi: Fertility and Sterility (keterangan: ada di ClinicalKey) vol. 103 no. 02 (Feb. 2015), page 367-373.
Topik: Estradiol; in vitro fertilization; intracytoplasmic sperm injection; luteal phase support; progesterone; meta-analysis

Ketersediaan

Perpustakaan FK Nomor Panggil: F02.K Non-tandon: tidak ada Tandon: 1

Lihat Detail Induk

Isi artikel

Objective To evaluate whether the addition of E2 for luteal phase support (LPS) in IVF/intracytoplasmic sperm injection (ICSI) could improve the outcome of clinical pregnancy. Design Meta-analysis. Setting University hospital center. Patient(s) Women underwent IVF or ICSI using the GnRH agonist or GnRH antagonist protocol. Intervention(s) Progesterone alone or combined with E2 for LPS. Main Outcome Measure(s) Clinical pregnancy rate per patient (CPR/PA), clinical pregnancy rate per ET, implantation rate, ongoing pregnancy rate per patient, clinical abortion rate, and ectopic pregnancy rate. Result(s) Fifteen relevant randomized controlled trials (RCTs) were identified that included a total of 2,406 patients. There was no statistical difference between E2 + P group and P-only group regarding the primary outcome of CPR/PA for different routes of administration of E2 (oral, vaginal, and transdermal) or other relevant outcome measures. No significant effect was observed for different daily doses of E2 (6, 4, and 2 mg), even through oral medication in CPR/PA. Conclusion(s) The best available evidence suggests that E2 addition during the luteal phase does not improve IVF/ICSI outcomes through oral medication, even with different daily doses. Furthermore, RCTs that study other administration routes are needed.

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