Optimal Serum Selenium Concentrations Are Associated with Lower Depressive Symptoms and Negative Mood among Young Adults  

Oleh:

Conner, Tamlin S ; Richardson, Aimee C ; Miller, Jody C.

Jenis: Article from Journal - ilmiah internasional
Dalam koleksi: JN: The Journal of Nutrition vol. 145 no. 01 (Jan. 2015), page 59-65.
Topik: selenium; micronutrients; mood; depression; young adults; daily diary method

Ketersediaan

Perpustakaan FK Nomor Panggil: J42.K Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

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Isi artikel

Background: There is evidence that low, and possibly high, selenium status is associated with depressed mood. More evidence is needed to determine whether this pattern occurs in young adults with a wide range of serum concentrations of selenium. Objective: The aim of this study was to determine if serum selenium concentration is associated with depressive symptoms and daily mood states in young adults. Methods: A total of 978 young adults (aged 17–25 y) completed the Center for Epidemiological Studies–Depression scale and reported their negative and positive mood daily for 13 d using an Internet diary. Serum selenium concentration was determined by inductively coupled plasma mass spectrometry. ANCOVA and regression models tested the linear and curvilinear associations between decile of serum selenium concentration and mood outcomes, controlling for age, gender, ethnicity, BMI, and weekly alcohol intake. Smoking and childhood socioeconomic status were further controlled in a subset of participants. Results: The mean ± SD serum selenium concentration was 82 ± 18 µg/L and ranged from 49 to 450 µg/L. Participants with the lowest serum selenium concentration (62 ± 4 µg/L; decile 1) and, to a lesser extent, those with the highest serum selenium concentration (110 ± 38 µg/L; decile 10) had significantly greater adjusted depressive symptoms than did participants with midrange serum selenium concentrations (82 ± 1 to 85 ± 1 µg/L; deciles 6 and 7). Depressive symptomatology was lowest at a selenium concentration of ~85 µg/L. Patterns for negative mood were similar but more U-shaped. Positive mood showed an inverse U-shaped association with selenium, but this pattern was less consistent than depressive symptoms or negative mood. Conclusions: In young adults, an optimal range of serum selenium between ~82 and 85 µg/L was associated with reduced risk of depressive symptomatology. This range approximates the values at which glutathione peroxidase is maximal, suggesting that future research should investigate antioxidant pathways linking selenium to mood.

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