Chikungunya Virus and the Global Spread of a Mosquito-Borne Disease  

Oleh:

Weaver, Scott C. ; Lecuit, Marc

Jenis: Article from Journal - ilmiah internasional
Dalam koleksi: The New England Journal of Medicine (keterangan: ada di Proquest) vol. 372 no. 13 (Mar. 2015), page 1231-1239.

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Perpustakaan FK Nomor Panggil: N08.K Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

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Isi artikel

hikungunya virus is a mosquito-borne alphavirus; its name comes from a Makonde word describing the bent posture of persons with the severe arthralgia that is a hallmark of chikungunya fever, the disease caused by the virus.1 Chikungunya virus was first isolated after a 1952–1953 epidemic in present-day Tanzania. Outbreaks were subsequently identified in Asia during the 1950s and 1960s. Like the related alphaviruses found in Australia and other parts of Oceania, as well as in South America, chikungunya virus causes an acute febrile illness that is typically accompanied by severe arthralgia. Alphaviruses have a single-stranded, positive-sense RNA genome approximately 11.5 kb in length that encodes four nonstructural proteins and three main structural proteins: the capsid and two envelope glycoproteins, E1 and E2, which form spikes on the virion surface .2,3 E2 binds to unknown cellular receptors to initiate cell entry through endocytosis, and E1 includes a fusion peptide, exposed at low pH in endosomes, which initiates the release of nucleocapsids into the host-cell cytoplasm.

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