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ArtikelTwenty-first-century oral hairy leukoplakia—a non–HIV-associated entity  
Oleh: Rachmiel, Adi ; Conn, Brenden ; Pemberton, Michael ; Robinson, Max ; Banks, Rob
Jenis: Article from Journal - ilmiah internasional
Dalam koleksi: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology (keterangan: ada di ClinicalKey) vol. 119 no. 03 (Mar. 2015), page 326-332.
Ketersediaan
  • Perpustakaan FK
    • Nomor Panggil: O04.K
    • Non-tandon: 1 (dapat dipinjam: 0)
    • Tandon: tidak ada
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Isi artikelObjective This study presents the clinicopathologic features of a series (N = 35) of patients with non–human immunodeficiency virus (HIV)–associated oral hairy leukoplakia (OHL). Methods Patients with non–HIV-associated OHL were identified from three centers. Epstein-Barr virus infection was demonstrated by using EBV early ribonucleic acid in situ hybridization. The presence of Candida co-infection was evaluated by diastase periodic acid–Schiff staining. The clinical features were determined by review of the medical records. Results Twenty-eight patients had intercurrent respiratory problems requiring long-term steroid inhaler use, four suffered from autoimmune diseases requiring immunosuppressant therapy, and four had diabetes. The majority of lesions were located on the tongue, and 24 showed evidence of Candida co-infection. Conclusions In the twenty-first century, the presence of OHL should not be regarded as pathognomic for HIV infection or significant systemic immunosuppression. Local and systemic immunosuppression, in the form of steroid inhaler use, is a risk factor for the development of OHL.
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