Expression and localization of osteopontin, homing cell adhesion molecule/CD44, and integrin avß3 in mucoepidermoid carcinoma and acinic cell adenocarcinoma of salivary gland origin  

Oleh:

Fok, T.C. ; Lapointe, H. ; Tuck, A.B. ; Chambers, A.F. ; Jackson-Boeters, L.

Jenis: Article from Journal - ilmiah internasional
Dalam koleksi: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology (keterangan: ada di ClinicalKey) vol. 118 no. 03 (Sep. 2014), page 320–329 .

Ketersediaan

Perpustakaan FK Nomor Panggil: O04.K Non-tandon: tidak ada Tandon: 1

Lihat Detail Induk

Isi artikel

Objective Osteopontin (OPN) plays a role in tumor progression. This study aimed to determine the expression of OPN, CD44, and integrin avß3 in pleomorphic adenoma (PA), acinic cell adenocarcinoma (ACA), and mucoepidermoid carcinoma (MEC). Study Design Immunohistochemistry was used to semiquantify the levels of expression of OPN and its receptors in normal salivary glands (NSG) (n = 20), PA (n = 20), ACA (n = 11), and MEC (n = 29). Results OPN expression was increased in ACA and MEC compared with PA and NSG (median scores, 6, 6, 4, and 4, respectively). CD44 expression was increased in ACA and reduced in MEC and PA compared with NSG (median scores, 8, 4, 3, and 5, respectively). Integrin avß3 median scores were 5 in ACA, 1 in MEC, and 0 in PA and NSG. Conclusions OPN is expressed in salivary gland tumors and is at higher levels in ACA and MEC.

Opini Anda

Klik untuk menuliskan opini Anda tentang koleksi ini!

Kembali