Prognostic value of residual node involvement after induction chemotherapy in operable oral squamous cell carcinoma  

Oleh:

Jiong, Lyu0 ; Yi, Zhong ; Chaojun, Li ; Hao, Song ; Guoxin, Ren ; Wei, Guo

Jenis: Article from Journal - ilmiah internasional
Dalam koleksi: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology (keterangan: ada di ClinicalKey) vol. 118 no. 03 (Sep. 2014), page 295–299 .

Ketersediaan

Perpustakaan FK Nomor Panggil: O04.K Non-tandon: tidak ada Tandon: 1

Lihat Detail Induk

Isi artikel

Objective The aim of this study was to assess the prognostic value of residual node involvement after induction chemotherapy (ICT) for head and neck squamous cell carcinoma and to investigate post-ICT node status associated with tumor characteristics. Study Design We retrospectively analyzed a cohort of 109 patients with operable oral squamous cell carcinoma who underwent ICT followed by surgery with neck dissection. The median follow-up was 45 months. The primary endpoints were overall survival (OS) and disease-free survival (DFS). Results After ICT, 48 patients (44.0%) had no positive nodes, 46 (42.2%) had 1 to 3 residual nodes, and 15 (13.7%) had more than 3 residual nodes. The number of residual nodes was significantly associated with OS and DFS. On multivariate analysis, the number of residual nodes was an independent prognostic factor (P = .011 for DFS and P = .034 for OS). Conclusions Although constituting a different parameter from primary surgery data, the number of positive nodes could remain a prognostic factor even after ICT (at secondary surgery).

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