Distribusi Defisiensi Glucose-6-Phosphate Dehydrogenase (G-6-PD) pada Berbagai Populasi Masyarakat di Indonesia  

Oleh:

Lanni, Fransiska

Jenis: Article from Journal - ilmiah nasional - tidak terakreditasi DIKTI
Dalam koleksi: Biota Jurnal Ilmiah Ilmu-ilmu Hayati vol. IX no. 1 (Feb. 2004), page 47-53.
Topik: G-6-PD deficiency; genetic marker; malarial endemic; Indonesian populations

Ketersediaan

Perpustakaan Pusat (Semanggi) Nomor Panggil: BB74.1 Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

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Isi artikel

Glucose-6-phosphate dehydrogenase (G-6-PD) deficiency is the most common human enzymopathy, nearly 400 different biochemical variants of the enzyme have been described worldwide. The heterogeneity of these abnormal hemoglobins are very extensive in some populations such as the results of malarial natural selection and the use as genetic markers for certain populations. As in other malarious areas in Southesat Asia, the presence of G-6-PD deficiency in most Indonesians might be prevalent. Nevertheless the frequencies and epidemiological distribution of these hereditary blood diseases among Indonesians has not been well known yet. This study have screened 2 059 unrelated, apparently healthy adult blood samples from 17 different populations. The present investigation had shown that the G-6-PD deficiency was commonly found in lesser Sunda populations sample, hold beyond Bali to the east in significant frequencies range from 5 % to 13.5%.

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