Multiple-System Atrophy  

Oleh:

Fanciulli, Alessandra ; Wenning, Gregor K.

Jenis: Article from Journal - ilmiah internasional
Dalam koleksi: The New England Journal of Medicine (keterangan: ada di Proquest) vol. 372 no. 03 (Jan. 2015), page 249-263.

Ketersediaan

Perpustakaan FK Nomor Panggil: N08.K Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

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Isi artikel

Multiple-system atrophy is an adult-onset, fatal neurodegenerative disease characterized by progressive autonomic failure, parkinsonian features, and cerebellar and pyramidal features in various combinations. It is classified as the parkinsonian subtype if parkinsonism is the predominant feature and as the cerebellar subtype if cerebellar features predominate. With its variable clinical presentations, multiple-system atrophy presents a major diagnostic challenge not only in neurology but also in other specialties, including cardiology, gastroenterology, urology, otolaryngology, and sleep medicine. Despite having faster motor progression, multiple-system atrophy may masquerade as Parkinson’s disease or idiopathic late-onset cerebellar ataxia until advanced stages of the disease. The history of multiple-system atrophy reflects the varied clinical manifestations of the disease. The term multiple-system atrophy was first coined in 1969 to pool three previously described neurologic entities: olivopontocerebellar atrophy, the Shy–Drager syndrome, and striatonigral degeneration.1 These entities correspond to multiple-system atrophy with predominantly cerebellar, autonomic, or parkinsonian features, respectively.

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