Integration of Acid–Base and Electrolyte Disorders  

Oleh:

Seifter, Julian L.

Jenis: Article from Journal - ilmiah internasional
Dalam koleksi: The New England Journal of Medicine (keterangan: ada di Proquest) vol. 371 no. 19 (Nov. 2014), page 1821-1831.
Topik: Integration of Acid–Base; Electrolyte Disorders

Ketersediaan

Perpustakaan FK Nomor Panggil: N08.K.2014.02 Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

Lihat Detail Induk

Isi artikel

This review describes a method of analyzing acid–base disorders that incorporates insights from the traditional, bicarbonate-centered model and the Stewart (or strong ion) model (Table 1Table 1Comparison of the Key Elements Associated with Two Models of Acid–Base Balance.).1-6 Acid–base balance and electrolyte homeostasis are intricately connected at the cellular level and in clinical disorders. This article emphasizes the integration of the principles of mass balance and electroneutrality — which are prominently featured in the strong ion model (also known as the physicochemical model) — for interpretation of acid–base phenomena. Most acid–base abnormalities can be diagnosed and interpreted with the use of the traditional approach. Why, then, should the strong ion theory be incorporated into teaching about acid–base balance? Although the Stewart model is not primarily a mathematical expression of a confirmed reality, it is relevant because it is a powerful construct that can shed light on an important biologic system.

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