Comparison of hemispheric activation during mental word and rhyme generation using transcranial Doppler sonography  

Oleh:

Krach, Sören ; Hartje, Wolfgang

Jenis: Article from Journal - ilmiah internasional
Dalam koleksi: Brain and Language (Full Text) vol. 96 no. 3 (2006), page 269-279.
Topik: Functional Doppler ultrasonography; Hemispheric language dominance; Word generation; Rhyme generation; Language lateralization
Fulltext: 96_03_Krach.pdf (617.38KB)

Isi artikel

The Wada test is at present the method of choice for preoperative assessment of patients who require surgery close to cortical language areas. It is, however, an invasive test with an attached morbidity risk. By now, an alternative to the Wada test is to combine a lexical word generation paradigm with non-invasive imaging techniques. However, results of this approach are still not in complete agreement with the Wndings of the Wada test (rD.92; Knecht, Deppe, Ebner et al., 1998). We attempted to obtain a more distinct language lateralization with the development of a phonological rhyme generation paradigm based on pseudoword stimuli. To examine the predictive value of both paradigms we performed simultaneous bilateral functional transcranial Doppler ultrasonography on 19 right-handed male native German subjects. The rhyme generation condition produced a signiWcantly stronger lateralization to the supposed hemisphere of language dominance than the classical word generation condition. The observed diVerences suggest that the rhyme generation paradigm is more robust in detecting hemispheric language dominance than other neuropsychological paradigms and might be most valuable for preoperative assessment of cortical language areas.

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