Comparing language lateralization determined by dichotic listening and fMRI activation in frontal and temporal lobes in children with epilepsy  

Oleh:

Fernandes, M.A. ; Smith, M.L. ; Logan, W. ; Crawley, A. ; McAndrews, M.P.

Jenis: Article from Journal - ilmiah internasional
Dalam koleksi: Brain and Language (Full Text) vol. 96 no. 1 (2006), page 106-114.
Topik: Language lateralization; Children; Epilepsy; Dichotic listening; fMRI; Temporal lobe; Frontal lobe; Localization; Laterality index
Fulltext: 96_01_Fernandes.pdf (210.75KB)

Isi artikel

We investigated the relationship between ear advantage scores on the Fused Dichotic Words Test (FDWT), and laterality of activation in fMRI using a verb generation paradigm in fourteen children with epilepsy. The magnitude of the laterality index (LI), based on spatial extent and magnitude of activation in classical language areas (BA 44/45, 21/22, 39) differed significantly for patients classified with unilateral left, compared to bilateral, language representation based on FDWT scores. Concordance with fMRI was higher for those classified with unilateral left, than bilateral language representation on the FDWT. Of note, asymmetry in temporal lobe, rather than frontal lobe, activation was more strongly related to the LI from the dichotic listening test. This study shows that the FDWT can provide a quick and valid estimate of lateralization in pre-surgical candidates, which can be readily adopted for other clinical or research purposes when an estimate of language dominance is desired.

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