Reorganization of the cerebro-cerebellar network of language production in patients with congenital left-hemispheric brain lesions  

Oleh:

Lidzba, K. ; Wilke, M. ; Staudt, M. ; Krageloh-Mann, I. ; Grodd, W.

Jenis: Article from Journal - ilmiah internasional
Dalam koleksi: Brain and Language (Full Text) vol. 106 no. 3 (2008), page 204-210.
Topik: Brain lesion; Cerebellum; Language reorganization; Children
Fulltext: 106_03_Lidzba-V1.pdf (742.16KB)

Isi artikel

Patients with congenital lesions of the left cerebral hemisphere may reorganize language functions into the right hemisphere. In these patients, language production is represented homotopically to the left-hemispheric language areas. We studied cerebellar activation in five patients with congenital lesions of the left cerebral hemisphere to assess if the language network is reorganized completely in these patients, i.e. including also cerebellar language functions. As compared to a group of controls matched for age, sex, and verbal IQ, the patients recruited an area not in the right but in the left cerebellar hemisphere. The extent of laterality of the cerebellar activation correlated significantly with the laterality of the frontal activation. We suggest that the developing brain reacts to early focal lesions in the left hemisphere with a mirror-image organization of the entire cerebro-cerebellar network engaged in speech production.

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