Primary progressive aphasia: Linguistic patterns and clinical variants  

Oleh:

Silveri, Maria Caterina ; Pravata, Emanuele ; Brita, Anna Clelia ; Improta, Erika ; Ciccarelli, Nicoletta ; Rossi, Paola ; Colosimo, Cesare

Jenis: Article from Journal - ilmiah internasional
Dalam koleksi: Brain and Language (Full Text) vol. 135 (2014), page 57-65.
Topik: Primary progressive aphasia; Apraxia of speech; Semantic deficit; Phonological deficit; Agrammatism; Semantic dementia; Alzheimer’s disease; Corticobasal degeneration
Fulltext: 135_Silveri.pdf (700.4KB)

Isi artikel

We investigated whether primary progressive aphasias (PPA) reflect non-random degradation of linguistic dimensions that might be supported by different neural subsystems and to what extent this degradation contributes to the emergence of clinical entities: semantic (S), logopenic (L) and nonfluent (NF) aphasia; apraxia of speech was also considered if associated with language disorders (AOS/aph). Fortytwo aphasic patients are reported. Two main definable patterns of linguistic deficits tended to emerge that corresponded with identifiable patterns of brain atrophy, and probably diseases: the S variant, which principally expresses the impact of a ‘‘deep’’ cognitive (semantic) disorder on language, and AOS/aph in which ‘‘peripheral’’ executive components play a significant role. By contrast, NF aphasia emerged as a heterogeneous variant due to disorganization of various dimensions within the linguistic domain, that assumes different patterns depending on the differential distribution of atrophy in the perisylvian regions

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