Early gray-matter and white-matter concentration in infancy predict later language skills: A whole brain voxel-based morphometry study  

Oleh:

Can, Dilara Deniz ; Richards, Todd ; Kuhl, Patricia K.

Jenis: Article from Journal - ilmiah internasional
Dalam koleksi: Brain and Language (Full Text) vol. 124 no. 1 (2013), page 34-44.
Topik: Voxel-based morphometry; Infancy; Cerebellum; Hippocampus; Posterior limb of the internal capsule (PLIC); Cerebral peduncle; Expressive language; Receptive language
Fulltext: 124_01_Can.pdf (1,007.69KB)

Isi artikel

Magnetic Resonance Imaging (MRI) brain scans were obtained from 19 infants at 7 months. Expressive and receptive language performance was assessed at 12 months. Voxel-based morphometry (VBM) identified brain regions where gray-matter and white-matter concentrations at 7 months correlated significantly with children’s language scores at 12 months. Early gray-matter concentration in the right cerebellum, early white-matter concentration in the right cerebellum, and early white-matter concentration in the left posterior limb of the internal capsule (PLIC)/cerebral peduncle were positively and strongly associated with infants’ receptive language ability at 12 months. Early gray-matter concentration in the right hippocampus was positively and strongly correlated with infants’ expressive language ability at 12 months. Our results suggest that the cerebellum, PLIC/cerebral peduncle, and the hippocampus may be associated with early language development. Potential links between these structural predictors and infants’ linguistic functions are discussed.

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