The effect of nitrous oxide inhalation on the hypotensive response to propofol: a randomized controlled trial  

Oleh:

Yokoe, Chizuko ; Hanamoto, Hiroshi ; Boku, Aiji ; Sugimura, Mitsutaka ; Morimoto, Yoshinari

Jenis: Article from Journal - ilmiah internasional
Dalam koleksi: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology (keterangan: ada di ClinicalKey) vol. 118 no. 02 (Aug. 2014), page 166–173.
Topik: nitrous oxipropofolde inhalation; hypotensive;

Ketersediaan

Perpustakaan FK Nomor Panggil: O04.K Non-tandon: tidak ada Tandon: 1

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Isi artikel

Objective Decrease in arterial blood pressure is a prominent adverse reaction during propofol (Disoprivan; AstraZeneca K.K., Osaka, Japan) sedation. The purpose of this prospective randomized study was to explore the effects of nitrous oxide (N2O) on the hypotensive response during propofol sedation. Study design Twenty-six healthy volunteers received intravenous sedation with propofol alone (group P, n=13) or a combined technique using 20% N2O and propofol (group N+P, n=13). Propofol was administered by a target-controlled infusion system to attain and maintain a plasma propofol concentration of 1.5 µg/mL. Hemodynamic and autonomic parameters were measured. Results Mean arterial pressure decreased in both groups, the hypotensive response in group N+P being significantly smaller than in group P. Reduction in the low-frequency power of systolic blood pressure variability, indicative of sympathetic nervous activity, was also smaller in group N+P than in group P. Conclusions Addition of N2O to propofol sedation can attenuate the hypotensive effect of propofol.

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