Use of BRAF V600E as a Molecular Marker in Aggressive Colorectal Cancer  

Oleh:

Hernowo, Bethy S. ; Ariyanni, Fenny ; Suryanti, Sri ; Hassan, Abdul H

Jenis: Article from Journal - ilmiah nasional - terakreditasi DIKTI
Dalam koleksi: Acta Medica Indonesiana vol. 46 no. 02 (Apr. 2014), page 104-110.
Topik: BRAF V600E; Dukes; immunoexpression; colorectal carcinoma.
Fulltext: hal 104 Use of BRAF V600E as a Molecular Marker in Aggressive.pdf (884.02KB)

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Perpustakaan FK Nomor Panggil: A02.K Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

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Isi artikel

to compare the immunoexpression of BRAF V600E among stage of colorectal cancer. Methods: this was a cross sectional, and retrospective study involving Dukes’ stage A, B, and C colorectal carcinoma, each with 15 cases. Immunohistochemistry was performed in paraffin-embedded specimens of tumor mass for the assessment of BRAF V600E. The proportion differences of immunoexpression of BRAF V600E among Dukes’stage A, B, and C were tested using Chi-Square test. Results: the result of positive BRAF V600E immunoexpression (moderately to strongly positive) in Dukes’stage A, B, and C were found in 1 of 15 cases, 4 of 15 cases and 13 of 15 cases respectively. BRAF V600E immunoexpression was statistically significant more frequent in Dukes’stage C (p<0,001, Chi-Square test). Conclusion: positive BRAF V600E immunoexpression could be used as a marker of aggresive colorectal carcinoma.

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