Hypercalcemia of Malignancy: Clinical Characteristics and Treatment Outcome  

Oleh:

Wijaya, Indra ; Oehadian, Amaylia ; Sumantri, Rachmat

Jenis: Article from Journal - ilmiah nasional - terakreditasi DIKTI - non-atma jaya
Dalam koleksi: Majalah Kedokteran Bandung (Bandung Medical Journal) vol. 46 no. 02 (Jun. 2014), page 111-117.
Topik: Bisphosphonate; hypercalcemia of malignancy; rehydration; Bisfosfonat; hiperkalsemia pada keganasan; rehidrasi
Fulltext: MKB_46_02_09_Wijaya.pdf (1.32MB)

Ketersediaan

Perpustakaan FK Nomor Panggil: M54.K Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

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Isi artikel

Hypercalcemia is one of the most common paraneoplastic syndromes in hospitalized malignancy patients. The aim of this study was to determine the clinical characteristics and treatment outcome in hypercalcemia of malignancy. This was a study using medical records of patients with malignancy hospitalized in the Departement of Internal Medicine, Dr. Hasan Sadikin Hospital Bandung between December 2008 and March 2011. Statistical analysis was performed by Wilcoxon and Mann-Whitney tests. There were 40 patients with hypercalcemia of malignancy, consisted of 22 hematologic malignancies and 18 solid tumors. Disturbance of consiousness were found in 4, dehydration in 18, constipation in 6, and nausea and vomiting in 6 subjects. In 16 subjects, no symptoms were found. All subjects received rehydration with normal saline. Bisphosphonate was given in 26 subjects. The difference of decreasing ion calcium level, between the groups who were treated with or without bisphosphonate was 0.59 (0.01–1.17) mg/dL, p=0.0001. In conclusion, hematologic and solid tumors are found in about the same proportion in hypercalcemia associated malignancy. Treatment either with or without bisphosphonate shows good results.

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