Comparison of fluorodeoxyglucose uptake in symptomatic carotid artery and stable femoral artery plaques  

Oleh:

Shaikh, S. ; Welch, A. ; Ramalingam, S. L. ; Murray, A. ; Wilson, H. M.

Jenis: Article from Article - diterbitkan di jurnal ilmiah internasional
Dalam koleksi: BJS: British Journal of Surgery vol. 101 no. 04 (Mar. 2014), page 363-370.

Ketersediaan

Perpustakaan FK Nomor Panggil: B15.K.2014.01 Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

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Isi artikel

Background Fluorine-18-labelled fluoroxdeoxyglucose (FDG) positron emission tomography (PET) has been used to evaluate atherosclerotic plaque metabolic activity, and through its uptake by macrophages is believed to have the potential to identify vulnerable plaques. The aims were to compare FDG uptake in carotid plaques from patients who had sustained a recent thromboembolic cerebrovascular event with that in femoral artery plaques from patients with leg ischaemia, and to correlate FDG uptake with the proportion of M1 and M2 macrophages present. Methods Consecutive patients who had carotid endarterectomy for symptomatic, significant carotid stenosis and patients with severe leg ischaemia and significant stenosis of the common femoral artery underwent FDG-PET and histological plaque analysis. The voxel with the greatest activity in the region of interest was calculated using the Patlak method over 60?min. Plaques were dual-stained for CD68, and M1 and M2 macrophage subsets. Results There were 29 carotid and 25 femoral artery plaques for study. The maximum dynamic uptake was similar in carotid compared with femoral plaques: median (range) 9·7 (7·1–12·2) versus 10·0 (7·4–16·6) respectively (P?=?0·281). CD68 macrophage counts were significantly increased in carotid compared with femoral plaques (39·5 (33·9–50·1) versus 11·5 (7·7–21·3) respectively; P?

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