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Randomized clinical trial of single- versus multi-incision laparoscopic cholecystectomy
Oleh:
Jorgensen, L. N.
;
Rosenberg, J.
;
Al-Tayar, H.
;
Assaadzadeh, S.
;
Helgstrand, F.
;
Bisgaard, T.
Jenis:
Article from Article - diterbitkan di jurnal ilmiah internasional
Dalam koleksi:
BJS: British Journal of Surgery vol. 101 no. 04 (Mar. 2014)
,
page 347-355.
Ketersediaan
Perpustakaan FK
Nomor Panggil:
B15.K.2014.01
Non-tandon:
1 (dapat dipinjam: 0)
Tandon:
tidak ada
Lihat Detail Induk
Isi artikel
Background There are no randomized studies that compare outcomes after single-incision (SLC) and conventional multi-incision (MLC) laparoscopic cholecystectomy under an optimized perioperative analgesic regimen. Methods This patient- and assessor-blinded randomized three-centre clinical trial compared SLC and MLC in women admitted electively with cholecystolithiasis. Outcomes were registered on the day of operation (day 0), on postoperative days 1, 2, 3 and 30, and 12?months after surgery. Blinding of the patients was maintained until day 3. The primary endpoint was pain on movement measured on a visual analogue scale, reported repeatedly by the patient until day 3. Results The intention-to-treat population comprised 59 patients in the SLC and 58 in the MLC group. There was no significant difference between the groups with regard to any of the pain-related outcomes, on-demand administration of opioids or general discomfort. Median duration of surgery was 32·5?min longer in the SLC group (P?0·001). SLC was associated with a reduced incidence of vomiting on day 0 (7 versus 22 per cent; P?=?0·019). The incidences of wound-related problems were comparable. One patient in the SLC group experienced a biliary leak requiring endoscopic retrograde cholangiopancreatography. The rates of incisional hernia at 12-month follow-up were 2 per cent in both groups. Cosmetic rating was significantly improved after SLC at 1 and 12?months (P?0·001). Conclusion SLC did not significantly diminish early pain in a setting with optimized perioperative analgesic patient care. SLC may reduce postoperative vomiting
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