Quality of life and other patient-reported outcomes following exenteration for pelvic malignancy  

Oleh:

Young, J. M. ; Badgery-Parker, T. ; Masya, L. M. ; King, M. ; Koh, C.

Jenis: Article from Article - diterbitkan di jurnal ilmiah internasional
Dalam koleksi: BJS: British Journal of Surgery vol. 101 no. 03 (Feb. 2014), page 277-287.

Ketersediaan

Perpustakaan FK Nomor Panggil: B15.K.2014.01 Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

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Isi artikel

Background Pelvic exenteration is highly radical surgery offering the only potential cure for locally advanced pelvic cancer. This study compared quality of life and other relevant patient-reported outcomes over 12?months for patients who did and those who did not undergo pelvic exenteration. Methods Consecutive patients referred for consideration of pelvic exenteration completed clinical and patient-reported outcome assessments at baseline, hospital discharge (exenteration patients only), and 1, 3, 6, 9 and 12?months. Outcomes included cancer-specific quality of life (Functional Assessment of Cancer Therapy – Colorectal; FACT-C), physical and mental health status (Short Form 36 version 2), psychological distress (Distress Thermometer), and pain (study-specific composite) scores. Linear mixed modelling compared trajectories between exenteration and no-exenteration groups. Results Among 182 patients, 148 (81.3 per cent) proceeded to exenteration. There were no baseline differences between the two groups. Among patients who had exenteration, the mean FACT-C score at baseline of 93.0 had reduced by 14·4 points at hospital discharge, but increased to 86·7 at 1?month after surgery and continued to improve, returning to baseline by 9?months. For patients in the no-exenteration group, FACT-C scores decreased between baseline and 1?month, increased slowly to 6?months and then began to decline at 9?months. There were few statistically or clinically significant differences in any patient-reported outcomes between the groups. Conclusion Quality of life and related patient-reported outcomes improve rapidly after pelvic exenteration surgery. For 9?months after surgery, these outcomes are comparable with those of similar do patients who do not have surgery; thereafter, there is a decline in patients who do not have exenteration. Pelvic exenteration can be performed with acceptable quality of life and patient-reported outcomes.

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