A CFD Study of a pMDI Plume Spray  

Oleh:

Oliveira, Ricardo F. ; Ferreira, Ana C. ; Teixeira, Senhorinha F. ; Teixeira, Jose C. ; Cabral-Marques, Helena

Jenis: Article from Books - E-Book
Dalam koleksi: Transactions on Engineering Technologies: Special Volume of the World Congress on Engineering 2013, page 163-176.
Topik: Computational fluid dynamics; Discrete phase model; Drug particles; Lagrangian tracking; pMDI; Spray characterization
Fulltext: 13_978-94-017-8831-1_Oliviera_Ferreira_Teixeira.pdf (706.15KB)

Isi artikel

Asthma is an inflammatory chronic disease characterized by airway obstructions disorders. The treatment is usually done by inhalation therapy, in which pressurized metered-dose inhalers (pMDIs) are preferred devices. The objective of this paper is to characterize and simulate a pMDI spray plume by introducing realistic factors through a computational fluid dynamics (CFD) study. Numerical simulations were performed with Fluent® software, by using a three-dimensional “testbox” for room environment representation. A salbutamol/HFA-134a formulation was used for characterization, whose properties taken as input for the CFD simulations. Spray droplets were considered to be composed by ethanol, salbutamol and HFA-134a. Propellant evaporation was taken into consideration, as well as, drag coefficient correction. Results showed an air temperature drop of 3.3 °C near the nozzle. Also, an increase in air velocity of 3.27 m/s was noticed. The CFD results seem to be in good agreement with Dunbar (1997) data on particle average velocity along the axial distance from the nozzle.

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