Epidermodysplasia verruciformis - symptoms, causes, diagnosis and treatment  

Oleh:

Sutejo, Richard

Jenis: Article from Journal - ilmiah nasional - tidak terakreditasi DIKTI
Dalam koleksi: Cermin Dunia Kedokteran vol. 41 no. 05/216 (May 2014), page 342-346.
Topik: Epidermodysplasia verruciformis; HPV; biopsy; imiquimod; surgery; biopsi; bedah
Fulltext: 08_216.pdf (1.01MB)

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Perpustakaan FK Nomor Panggil: C04.K.2014 Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

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Epidermodysplasia verruciformis is a rare dermal disease made popular by “Tree Man” in November 2007. The disease is caused by rare autosomal recessive hereditary genetic disorder located on chromosome 17 which causes mutation on EVER1 and EVER2 genes. An abnormality in Major Histocompatibility Complex Class II (MHC II) allele DC-DQ has also been documented in patients in America, Europe and Africa continents. These mutations increased vulnerabilities to Human Papillomavirus (HPV) causing uncontrolled wart growth, prominent in arms, neck, and legs. The common initial detection of Epidermodysplasia verruciformis is through biopsy on predicted premalignant and malignant skin lesions. Further confi rmatory analysis can be performed by in-situ hybridization and polymerase chain reaction. The medical treatment is generally not defi nitive; typically with topical drugs such ad imiquimod, 5-fl uorouracil, vitamin A derivative 13-cis retinoic acid, interferon alpha or cholecalciferol analogues (Vitamin D). For severe cases, surgical procedures to remove excessive warts are necessary.

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