Randomized clinical trial of perioperative omega-3 fatty acid supplements in elective colorectal cancer surgery  

Oleh:

Sorensen, L. S. ; Thorlacius-Ussing, O. ; Schmidt, E. B. ; Rasmussen, H. H. ; Lundbye-Christensen, S.

Jenis: Article from Article - diterbitkan di jurnal ilmiah internasional
Dalam koleksi: BJS: British Journal of Surgery vol. 101 no. 02 (Jan. 2014), page 33-42.
Fulltext: hal33-42.pdf (133.06KB)

Ketersediaan

Perpustakaan FK Nomor Panggil: B15.K.2014.01 Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

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Isi artikel

Background: Omega-3 fatty acids (n-3 FAs) may have beneficial clinical effects, and n-3 FA supplements may improve outcome after surgery. Methods: In a randomized double-blind placebo-controlled trial in single centre, patients referred for elective colorectal cancer surgery received either an n-3 FA-enriched oral nutritional supplement (ONS) (Supportan?, 200 ml twice daily) providing 2·0 g eicosapentaenoic acid (EPA) and 1·0 g docosahexaenoic acid (DHA) per day, or a standard isocaloric and isonitrogenous ONS, for 7 days before and 7 days after surgery. The primary endpoint was infectious and non-infectious complications within 30 days of surgery. Secondary endpoints were length of hospital stay, intensive care unit admission, readmissions, and concentrations of marine n-3 FAs and arachidonic acid in granulocyte membranes. Results: Some 148 consecutive patients (68 women, 80 men; mean age 71 (range 41–89) years) were randomized. There was no significant difference between groups in infectious or non-infectious postoperative complications (P =1·000). Granulocyte levels of EPA, DHA and docosapentaenoic acid (DPA) were significantly higher in the n-3 FA-enriched supplement group compared with the control group (P <0·001). The arachidonic acid level in granulocytes was significantly lower in the enriched group than in the control group (P <0·001). Conclusion: EPA, DHA and DPA were incorporated into granulocytes in patients receiving n-3 FAs, but this was not associated with improved postoperative outcomes

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