Interleukin-1beta -511T>C genetic variant contributes to recurrent pregnancy loss risk and peripheral natural killer cell proportion  

Oleh:

Jung, O Kim ; Woo, Sik Lee ; Bo, Eun Lee ; Young, Joo Jeon ; Young, Ran Kim

Jenis: Article from Journal - ilmiah internasional
Dalam koleksi: Fertility and Sterility (keterangan: ada di ClinicalKey) vol. 102 no. 01 (Jul. 2014), page 206–212.
Topik: IL-1ß -511T>C; polymorphism; NK cell; RPL; recurrent pregnancy loss

Ketersediaan

Perpustakaan FK Nomor Panggil: F02.K.2014.02 Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

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Isi artikel

Objective To identify whether interleukin gene polymorphisms are risk factors for idiopathic recurrent pregnancy loss (RPL) in Korean women. Design Case–control study. Setting Hospital-based study. Patient(s) A cohort of 385 idiopathic RPL patients and 232 controls with Korean ethnicity. Intervention(s) None. Main Outcome Measure(s) Genotyping was assessed with a polymerase chain reaction–restriction fragment length polymorphism assay. We examined polymorphisms in three interleukin (IL) genes: IL-1ß, IL-4, and IL-10. Result(s) The IL-1ß -511T>C polymorphism was associated with RPL (-511TT vs. -511CC: adjusted odds ratio 1.826; 95% confidence interval 1.130–2.953). Allelic gene–gene interaction analysis revealed that the T/B2/G (IL-1ß/IL-4/IL-10) allele combination was only detected in the RPL group (adjusted odds ratio 20.046; 95% confidence interval 1.188–338.204). The proportion of peripheral natural killer cells was higher in patients with the IL-1ß -511C allele compared with the -511T allele. Conclusion(s) According to these results, IL-1ß -511T>C may be a predisposing factor to RPL susceptibility. However, the mechanism underlying the function of IL-1ß -511T>C in RPL remains to be determined, and further studies are needed to improve understanding of the roles of IL-1ß -511T>C, using a larger and more heterogeneous cohort.

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