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Differences in ovarian hormones in relation to parity and time since last birth
Oleh:
Barrett, Emily S.
;
Parlett, Lauren E.
;
Windham, Gayle C.
;
Swan, Shanna H.
Jenis:
Article from Journal - ilmiah internasional
Dalam koleksi:
Fertility and Sterility (keterangan: ada di ClinicalKey) vol. 101 no. 06 (Jun. 2014)
,
page 1773–1780.
Topik:
Estradiol
;
fecundity
;
motherhood
;
menstrual cycle
;
ovarian function
Ketersediaan
Perpustakaan FK
Nomor Panggil:
F02.K.2014.02
Non-tandon:
1 (dapat dipinjam: 0)
Tandon:
tidak ada
Lihat Detail Induk
Isi artikel
Objective To examine ovarian function in relation to parity and time since last birth. Design Cross-sectional study. Setting Health-care program in California. Patient(s) 346 naturally cycling women, aged 18 to 39 years. Intervention(s) None. Main Outcome Measure(s) Mean follicular urinary estradiol metabolite concentration (E1C) (cycle days -8 to -1), mean luteal progesterone metabolite concentration (PdG) (days 0 to +10), and cycle phase lengths in ovulatory cycles. Result(s) After the women had collected daily urine samples for up to eight menstrual cycles, we measured the E1C and PdG using enzyme-linked immunoassay. The cycle phase lengths were calculated from the hormone profiles and daily diaries. Women who had given birth within the previous 3 years had lower E1C than the nulliparous women and women who last given birth >3 years earlier. Among the parous women, E1C was positively associated with the time since last birth. Women who last gave birth >3 years earlier had longer follicular phases than the nulliparous women. There were no associations between parity and PdG or luteal phase length. Conclusion(s) Our cross-sectional data suggest that ovarian function differs in nulliparous and parous women and is positively associated with the time since last birth. Longitudinal research is needed to explore within-woman changes in ovarian function prepartum and postpartum.
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