Sperm deoxyribonucleic acid damage in normozoospermic men is related to age and sperm progressive motility  

Oleh:

Belloc, Stephanie ; Benkhalifa, Moncef ; Cohen-Bacrie, Martine ; Dalleac, Alain ; Amar, Edouard ; Zini, Armand

Jenis: Article from Journal - ilmiah internasional
Dalam koleksi: Fertility and Sterility (keterangan: ada di ClinicalKey) vol. 101 no. 06 (Jun. 2014), page 1588–1593.
Topik: Sperm DNA fragmentation; infertility; normozoospermia; sperm motility; paternal age

Ketersediaan

Perpustakaan FK Nomor Panggil: F02.K.2014.02 Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

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Isi artikel

Objective To evaluate sperm DNA fragmentation in normozoospermic male partners of couples undergoing infertility evaluation. Design Retrospective cohort study. Setting Clinical andrology laboratory. Patient(s) A total of 1,974 consecutive normozoospermic men selected from a larger cohort of 4,345 consecutive, nonazoospermic men presenting for infertility evaluation. Intervention(s) None. Main Outcome Measure(s) Clinical parameters, conventional semen parameters, and sperm DNA fragmentation assessed by flow cytometry-based TUNEL assay and reported as percent sperm DNA fragmentation (%SDF). Result(s) The mean (±SD) %SDF and the proportion of men with high %SDF (>30%) were significantly lower in the normozoospermic compared with the entire cohort of 4,345 evaluable infertile men (17.6% ± 10.1% vs. 20.7% ± 12.4% and 11% vs. 20%, respectively). In the group of 1,974 normozoospermic men, %SDF was positively correlated with paternal age (r = 0.17) and inversely correlated with progressive motility (r = -0.26). In the subset of normozoospermic men with sperm parameters above the 50th percentile (=73 × 106 sperm/mL, =55% progressive motility, and =14% normal forms, World Health Organization 2010 guidelines), 5% (4 of 83) had elevated %SDF (>30%). Conclusion(s) In this large cohort of normozoospermic men presenting for infertility evaluation, DNA fragmentation level is related to sperm motility and paternal age, and 11% of these men have high levels of sperm DNA fragmentation. Furthermore, the data indicate that a nonnegligible proportion (5%) of normozoospermic men with high-normal sperm parameters may also have significant sperm DNA fragmentation.

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