GRM1 is upregulated through gene fusion and promoter swapping in chondromyxoid fibroma  

Oleh:

Nord, Karolin H ; Lilljebjorn, Henrik ; Vezzi, Francesco ; Nilsson, Jenny ; Magnusson, Linda

Jenis: Article from Journal - ilmiah internasional
Dalam koleksi: Nature Genetics vol. 46 no. 05 (May 2014), page 474 - 477.

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Perpustakaan FK Nomor Panggil: N12.K Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

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Nature Genetics | Letter Print Email Share/bookmark ????? GRM1 is upregulated through gene fusion and promoter swapping in chondromyxoid fibroma Karolin H Nord, Henrik Lilljebjörn, Francesco Vezzi, Jenny Nilsson, Linda Magnusson, Johnbosco Tayebwa, Danielle de Jong, Judith V M G Bovée, Pancras C W Hogendoorn & Karoly Szuhai Affiliations Contributions Corresponding author Nature Genetics 46, 474–477 (2014) doi:10.1038/ng.2927 Received 10 December 2013 Accepted 27 February 2014 Published online 23 March 2014 Article tools Full text PDF Citation Reprints Rights & permissions Article metrics Glutamate receptors are well-known actors in the central and peripheral nervous systems, and altered glutamate signaling is implicated in several neurological and psychiatric disorders. It is increasingly recognized that such receptors may also have a role in tumor growth. Here we provide direct evidence of aberrant glutamate signaling in the development of a locally aggressive bone tumor, chondromyxoid fibroma (CMF). We subjected a series of CMFs to whole-genome mate-pair sequencing and RNA sequencing and found that the glutamate receptor gene GRM1 recombines with several partner genes through promoter swapping and gene fusion events. The GRM1 coding region remains intact, and 18 of 20 CMFs (90%) showed a more than 100-fold and up to 1,400-fold increase in GRM1 expression levels compared to control tissues. Our findings unequivocally demonstrate that direct targeting of GRM1 is a necessary and highly specific driver event for CMF development.

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