Follicle number, not assessments of the ovarian stroma, represents the best ultrasonographic marker of polycystic ovary syndrome  

Oleh:

Christ, Jacob P. ; Willis, Amy D. ; Brooks, Eric D. ; Brink, Heidi Vanden ; Jarrett, Brittany Y.

Jenis: Article from Journal - ilmiah internasional
Dalam koleksi: Fertility and Sterility (keterangan: ada di ClinicalKey) vol. 101 no. 01 (Jan. 2014), page 280-287.
Topik: Polycystic ovary syndrome; ultrasound; follicle; stroma; hyperandrogenism

Ketersediaan

Perpustakaan FK Nomor Panggil: F02.K.2014.01 Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

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Isi artikel

Objective To compare the diagnostic potential of ultrasonographic markers of ovarian morphology, used alone or in combination, to predict polycystic ovary syndrome (PCOS). Design A diagnostic test study using cross-sectional data collected from 2006–2011. Setting Academic hospital and clinical research unit. Patient(s) Eighty-two women with PCOS and 60 healthy female volunteers. Intervention(s) None. Main Outcome Measure(s) Follicle number per ovary (FNPO), ovarian volume (OV), follicle number per single cross-section (FNPS), follicle distribution pattern, stromal area, ovarian area, stromal-to-ovarian area ratio (S:A), and stromal index (SI). Result(s) Follicle number per ovary best predicted PCOS (R2 = 67%) with 85% sensitivity and 98% specificity, followed by OV (R2 = 44%), and FNPS (R2 = 36%). Neither S:A nor SI had predictive power for PCOS. In combination, FNPO+S:A and FNPO+SI most significantly predicted PCOS (R2 = 74% vs. 73%, respectively). The diagnostic potentials of OV and FNPS were substantially improved when used in combination (OV+FNPO, R2 = 55%). Conclusion(s) As a single metric, FNPO best predicted PCOS. Although the addition of S:A or SI improved the predictive power of FNPO, gains were marginal, suggesting limited use in clinical practice. When image quality precludes a reliable estimation of FNPO, measurements of OV+FNPS provide the next closest level of diagnostic potential.

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