Should embryos developing to blastocysts on day 7 be cryopreserved and transferred: an analysis of pregnancy and implantation rates  

Oleh:

Kovalevsky, George ; Carney, Stacy M. ; Morrison, Linda S. ; Boylan, Caitlin F. ; Neithardt, Adrienne B.

Jenis: Article from Journal - ilmiah internasional
Dalam koleksi: Fertility and Sterility (keterangan: ada di ClinicalKey) vol. 100 no. 04 (Oct. 2013), page 1008-1012.
Topik: Frozen embryo transfer; blastocyst; day 7 blastocysts

Ketersediaan

Perpustakaan FK Nomor Panggil: F02.K.2013.02 Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

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Isi artikel

Objective To compare pregnancy rates (PRs) using blastocysts cryopreserved on day 7 with those cryopreserved on days 5 and 6. Design Retrospective observational cohort study. Setting Infertility center performing IVF. Patient(s) Eight hundred women with infertility undergoing frozen ET. Intervention(s) Blastocysts cryopreserved on days 5, 6, and 7 after retrieval were thawed and transferred. Main Outcome Measure(s) Ongoing PRs (pregnancy developing appropriately into the second trimester). Thaw survival, implantation rates, and clinical PRs were also calculated. Result(s) A total of 1,406 embryos were thawed with a survival of 90.7% for day 5, 83.7% for day 6, and 78.7% for day 7. Implantation rates were 43.3%, 28.9%, and 28.9%, respectively. Ongoing PRs were 43.9%, 32.9%, and 26.7%, respectively. Conclusion(s) Blastocysts cryopreserved on day 7 have a lower, but clinically important potential. Embryos that do not achieve blastocyst stage on day 6 should not be universally discarded, but should be observed in culture 1 more day as 27% may result in an ongoing pregnancy.

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