Serum Gastrin Level and Pepsinogen I/II Ratio as Biomarker of Helicobacter pylori Chronic Gastritis  

Oleh:

Arinton, I Gede

Jenis: Article from Journal - ilmiah nasional - terakreditasi DIKTI
Dalam koleksi: Acta Medica Indonesiana vol. 42 no. 3 (Jul. 2010), page 142-146.
Topik: dyspepsia; chronic gastritis; Helicobacter pylori; gastric cancer; polymerase chain reaction; PCR with ureC primer.
Fulltext: serum gastrin level.pdf (93.03KB)

Isi artikel

Aim: to find out biomarker as diagnostic tool of H. pylori chronic gastritis. Methods: the design of present study was a diagnostic test and there were 104 subjects with H. pylori chronic gastritis who fulfilled the inclusion and exclusion criteria. The diagnosis of H. pylori chronic gastritis was based on histopathological examination and PCR with ureC primer of the gastric biopsy specimen. In addition, we also performed the examination of serum gastrin, pepsinogen (PG) I and PG (pepsinogen) II level. By using analysis of receiver operating characteristic (ROC), an optimal cut off point of serum gastrin, PGI and PGII level as well as PGI/PGII ratio was determined. Analysis of bivariate logistic regression was used to determine the involved independent variables and possibilities as biomarkers. Significance level was determined by p value < 0.05. Results: we found optimal cut off points on serum gastrin, PGI and PGII level as well as the PGI/PGII ratio at 5.89 pmol/L; 82.5 µg/L; 6.48 µg/L and 13.6 respectively. By using the analysis of bivariate logistic regression, we found gastrin level with p = 0.078 (OR 2.75;95%CI 0.89-8.45) and PGI/PGII ratio with p = 0.000 (OR 14.63;95%CI 3.55-60.63). The opportunity of gastrin level and PGI/PGII ratio as biomarkers was 0.8 with 47% sensitivity, 83% specificity, 74% PPV, 61% NPV, 65% accuracy, LR+ = 2.76 and LR- = 0.64. Conclusion: gastrin level of >5.89 pmol/L and PGI/PGII ratio < 13.6 can be utilized as biomarkers of H. pylori chronic gastritis.

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