Adipokines, adiposity, and vasomotor symptoms during the menopause transition: findings from the Study of Women's Health Across the Nation  

Oleh:

Thurston, Rebecca C. ; Chang, Yuefang ; Mancuso, Peter ; Matthews, Karen A.

Jenis: Article from Journal - ilmiah internasional
Dalam koleksi: Fertility and Sterility (keterangan: ada di ClinicalKey) vol. 100 no. 03 (Sep. 2013), page 793-800.
Topik: Adipokines; adiposity; vasomotor symptoms; hot flashes

Ketersediaan

Perpustakaan FK Nomor Panggil: F02.K.2013.01 Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

Lihat Detail Induk

Isi artikel

Objective To test relationships between adipokines, adiposity, and vasomotor symptoms (VMS), including how these associations vary by menopause stage. Design A subcohort of the longitudinal cohort Study of Women's Health Across the Nation completed questionnaires, physical measures, and a fasting blood draw annually for 8 years. Associations between a poorer adipokine profile (lower adiponectin, lower high-molecular-weight [HMW] adiponectin, higher leptin, lower soluble leptin receptor, higher monocyte chemoattractant protein 1 [MCP-1]) and VMS were tested with the use of generalized estimating equations adjusting for potential confounders. Interactions by menopause stage (pre-/early perimenopause, late peri-/postmenopause) were tested. Setting Community. Patient(s) A total of 536 women ages 42–52 at baseline. Intervention(s) None. Main Outcome Measure(s) VMS. Result(s) Associations between adipokines and hot flashes varied by menopause stage, with a poorer adipokine profile associated with higher odds of hot flashes early in the transition (adiponectinlog: odds ratio [OR] 0.68, 95% confidence interval [CI] 0.51–0.90; HMW adiponectinlog: OR 0.70, 95% CI 0.58–0.85; leptinlog: OR 1.23, 95% CI 0.99–1.54; multivariable models including body mass index [BMI]), but not later in the transition. The direction of associations between BMI and VMS also varied by menopausal stage. Higher MCP-1 was associated with more night sweats (OR 1.37, 95% CI 1.06–1.76) across menopausal stages. Conclusion(s) An adverse adipokine profile was associated with more VMS, particularly early in the menopause transition.

Opini Anda

Klik untuk menuliskan opini Anda tentang koleksi ini!

Kembali