A common gene variant in STK11 is associated with metabolic risk markers and diabetes during gestation  

Oleh:

Bassols, Judit ; Megia, Ana ; Soriano-Rodriguez, Pilar ; Diaz, Marta ; Prats-Puig, Anna

Jenis: Article from Journal - ilmiah internasional
Dalam koleksi: Fertility and Sterility (keterangan: ada di ClinicalKey) vol. 100 no. 03 (Sep. 2013), page 788-792.
Topik: STK11; polymorphism; insulin; gestational diabetes

Ketersediaan

Perpustakaan FK Nomor Panggil: F02.K.2013.01 Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

Lihat Detail Induk

Isi artikel

Objective To assess whether the common rs8111699 (C528G) variant in STK11 is related to metabolic risk markers in pregnant women and to gestational diabetes mellitus (GDM). Design Cross-sectional study. Setting Hospital. Patient(s) A total of 561 pregnant women: 318 without and 243 with GDM (National Diabetes Data Group criteria). Intervention(s) None. Main Outcome Measures(s) rs8111699 variant in STK11 (Taqman technology). Fasting glucose, insulin (homeostatic model assessment of insulin resistance and ß-cell function [HOMA-IR and -ß]) and C-peptide assessed at 24–28 weeks’ gestation. Result(s) In non-GDM women, the G allele in rs8111699 was associated with lower HOMA-IR (CC: 1.3 ± 0.1 mIU/L; GG: 0.9 ± 0.1 mIU/L) and HOMA-ß (CC: 165 ± 20 mIU/L; GG: 118 ± 10 mIU/L). In GDM women, the G allele was related to lower body mass index (BMI; CC: 27.9 ± 1.0 kg/m2; GG: 24.5 ± 0.6 kg/m2) and C-peptide (CC: 2.3 ± 0.1 ng/mL; GG: 1.6 ± 0.1 ng/mL). The GG genotype was less frequently observed in GDM women (18% vs. 26%), particularly in heavier GDM women (BMI > median: 14% vs. 28%). Conclusion(s) In pregnant women, the G allele for the rs8111699 variant in STK11 is associated with a more favorable metabolic phenotype and may protect against the development of GDM, particularly in heavier women.

Opini Anda

Klik untuk menuliskan opini Anda tentang koleksi ini!

Kembali