Transforming growth factor-ß1 and its receptor soluble endoglin are altered in polycystic ovary syndrome during controlled ovarian stimulation  

Oleh:

Tal, Reshef ; Seifer, David B. ; Shohat-Tal, Aya ; Grazi, Richard V. ; Malter, Henry E.

Jenis: Article from Journal - ilmiah internasional
Dalam koleksi: Fertility and Sterility (keterangan: ada di ClinicalKey) vol. 100 no. 02 (Aug. 2013), page 538-543.
Topik: Polycystic ovarian syndrome (PCOS); transforming growth factor-ß1 (TGF-ß1); soluble endoglin (sENG); controlled ovarian stimulation (COS); angiogenesis

Ketersediaan

Perpustakaan FK Nomor Panggil: F02.K.2013.01 Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

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Isi artikel

Objective To evaluate the relationship between transforming growth factor (TGF)-ß1 and its receptor, soluble endoglin (sENG), in the serum and follicular fluid of women with polycystic ovarian syndrome (PCOS) compared with that of non-PCOS normal ovulating women during controlled ovarian stimulation (COS). Design Prospective case-control study. Setting Academic-affiliated assisted reproductive technology unit. Patient(s) Fourteen PCOS and 14 matched non-PCOS control women undergoing COS. Intervention(s) Serum was collected on day 3 (baseline), day of hCG, and day of retrieval. Follicular fluid (FF) was collected on day of oocyte retrieval. ELISA was performed to determine TGF-ß1 and sENG protein levels. Main Outcome Measure(s) Serum and FF levels of TGF-ß1 and sENG. Result(s) Serum TGF-ß1 did not change significantly during COS but was increased in PCOS compared with non-PCOS women on day 3 and days of hCG administration and oocyte retrieval. Serum sENG increased after hCG administration only in the non-PCOS control group. In addition, serum sENG was decreased in PCOS compared with non-PCOS control women on the days of hCG and retrieval. Accordingly, the bioavailability of TGF-ß1 (TGF-ß1/sENG ratio) was increased in women with PCOS compared with non-PCOS controls at all three time points. No differences in either factor were noted in FF between groups. Conclusion(s) The increased TGF-ß1 bioavailability in PCOS is not only due to increased TGF-ß1 levels but also to decreased levels of its receptor, sENG. These data suggest that increased TGF-ß1 bioavailability may contribute to the pathogenesis of PCOS and its increased risk for ovarian hyperstimulation.

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