Expression of adiponectin, leptin, and their receptors in ovarian endometrioma  

Oleh:

Choi, Youn Seok ; Oh, Hoon Kyu ; Choi, Jung-Hye

Jenis: Article from Journal - ilmiah internasional
Dalam koleksi: Fertility and Sterility (keterangan: ada di ClinicalKey) vol. 100 no. 01 (Jul. 2013), page 135-141.
Topik: Leptin; adiponectin; ObR; AdipoR; ovarian endometrioma

Ketersediaan

Perpustakaan FK Nomor Panggil: F02.K.2013.01 Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

Lihat Detail Induk

Isi artikel

Objective To evaluate the expression of leptin, leptin receptor (ObR), adiponectin, and adiponectin receptor (AdipoR) in ovarian endometriomas compared with normal endometrium, and to analyze relationships among adipokines and their receptors. Design Experimental study. Setting A clinic for the treatment of endometriosis and basic research laboratories. Patient(s) Forty-four women with endometriosis and 42 age-matched women with no laparoscopic evidence of endometriosis as control subjects. Intervention(s) Endometrial tissue samples were obtained during laparoscopic surgery. Main Outcome Measure(s) Immunohistochemical staining for leptin, ObR, adiponectin, and AdipoR was performed with the use of tissue microarray. Clinical characteristics were reviewed from the patient's medical records. The effect of leptin on the expression of adiponectin was evaluated in endometriotic cell line using real-time reverse-transcription polymerase chain reaction. Result(s) Positive expression rates of leptin and ObR were significantly higher in ovarian endometrioma compared with normal endometrium, but those of adiponectin and AdipoR were similar (ovarian endometrioma vs. normal endometrium, respectively: leptin 100% vs. 59.5%; ObR 72.7% vs. 33.3%; adiponectin 31.8% vs. 42.9%; AdipoR 88.6% vs. 73.8%). Expression of adipokines and their receptors did not show any correlation with disease stage. A positive correlation was found between expression of ObR and adiponectin (correlation coefficient 0.488; P=.001). Leptin treatment in endometriotic cells induced mRNA expression of adiponectin. Conclusion(s) These data suggest that leptin and its receptor are induced in ovarian endometriomas, and that the leptin/ObR system regulates adiponectin gene expression in endometriotic cells.

Opini Anda

Klik untuk menuliskan opini Anda tentang koleksi ini!

Kembali