In vitro fertilization–intracytoplasmic sperm injection outcome in patients with a markedly high DNA fragmentation index (>50%)  

Oleh:

Da, Shir ; Grover, Stephanie A. ; Moskovtsev, Sergey I. ; Swanson, Sonja ; Baratz, Ari

Jenis: Article from Journal - ilmiah internasional
Dalam koleksi: Fertility and Sterility (keterangan: ada di ClinicalKey) vol. 100 no. 01 (Jul. 2013), page 75-80.
Topik: DNA Fragmentation Index; ICSI; spermatozoa

Ketersediaan

Perpustakaan FK Nomor Panggil: F02.K.2013.01 Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

Lihat Detail Induk

Isi artikel

Objective To investigate differences in fertilization, clinical pregnancy, and miscarriage rates between men with a markedly high sperm DNA fragmentation index (DFI) (>50%) and those with low DFI (=15%) in couples matched by female partner age and ovarian reserve as determined by antimüllerian hormone (AMH) level. Design Retrospective cohort study. Setting University-affiliated fertility center. Patient(s) Men undergoing intracytoplasmic sperm injection (ICSI) cycles who had low (n = 114) or markedly high (n = 36) DNA damage. Intervention(s) None. Main Outcome Measure(s) Sperm DNA damage evaluated by acridine orange flow cytometry and expressed as the DFI, with the potential confounders of ovarian reserve and age controlled for by multivariable logistic regression analysis. Result(s) The fertilization and clinical pregnancy rates were not different between the two groups. We observed a trend toward a higher miscarriage rate with the high DFI group, but it did not reach statistical significance. Conclusion(s) Intracytoplasmic sperm injection in men with a high DFI with sperm selected by movement and morphology characteristics resulted in a similar pregnancy rate compared with the controls with a normal DFI. However, the trend observed of an increase in miscarriages suggests that any potential negative impact may appear later in development. Future studies involving a larger cohort may determine if the miscarriage trend reaches statistical significance.

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