The oncofetal protein IMP3: a novel biomarker and triage tool for premalignant atypical endometriotic lesions  

Oleh:

Vercellini, Paolo ; Cribiu, Fulvia Milena ; Del Gobbo, Alessandro ; Carcangiu, Maria Luisa ; Somigliana, Edgardo

Jenis: Article from Journal - ilmiah internasional
Dalam koleksi: Fertility and Sterility (keterangan: ada di ClinicalKey) vol. 99 no. 07 (Jun. 2013), page 1974-1979.
Topik: Endometriosis; endometrioma; atypical endometriosis; IMP3

Ketersediaan

Perpustakaan FK Nomor Panggil: F02.K.2013.04 Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

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Isi artikel

Objective To determine whether the oncofetal protein IMP3 is detectable in endometriomas with or without histological atypia and whether IMP3 staining can be used as a triage tool to identify foci of atypical endometriosis in doubtful cases. Design Retrospective study. Setting Academic department and referral center for endometriosis. Patient(s) A consecutive series of 516 women who underwent excision of 874 endometriomas. Intervention(s) Histological review by three expert pathologists and immunohistochemical staining for IMP3. Main Outcome Measure(s) Test performance of IMP3 immunohistochemistry versus first-round histology. Result(s) The prevalence of atypical endometriosis was 1.7% (95% confidence interval [CI], 0.9%–3.3%) based on the number of women and 1.0% (95% CI, 0.5%–1.9%) based on the number of cysts. Three cases of atypical endometriosis were identified at first-round histological examination. Immunohistochemistry detected seven of the eight cases diagnosed as preneoplastic atypia at second-round histology and one case diagnosed as reactive atypia at second-round histology. The sensitivity of first-round histology was 33.3%, compared with 88.9% of IMP3 immunohistochemistry. Conclusion(s) Immunohistochemical staining for IMP3 expression is a simple, inexpensive, and sensitive test that can be used in routine clinical practice as a triage tool to discriminate between cytological/structural atypia and confounding benign conditions.

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