Faster thrombin generation in women with polycystic ovary syndrome compared with healthy controls matched for age and body mass index  

Oleh:

Mendonça-Louzeiro, Maria Raquel Marques Furtado de ; Annichino-Bizzacchi, Joyce Maria ; Magna, Luis Alberto ; Quaino, Susan Kelly Picoli ; Benetti-Pinto, Cristina Laguna

Jenis: Article from Journal - ilmiah internasional
Dalam koleksi: Fertility and Sterility (keterangan: ada di ClinicalKey) vol. 99 no. 06 (May 2013), page 1786-1790.
Topik: Polycystic ovary syndrome; hemostatic markers; coagulation; fibrinolysis; venous thrombosis

Ketersediaan

Perpustakaan FK Nomor Panggil: F02.K.2013.04 Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

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Isi artikel

Objective To evaluate hemostatic markers in women with polycystic ovary syndrome (PCOS) compared with healthy controls matched for age and body mass index. Design Cross-sectional study. Setting Tertiary teaching hospital. Patient(s) Forty-five women with PCOS and 45 controls paired for age (±2 years) and body mass index (±2 kg/m2). Intervention(s) Clinical evaluation and venipuncture. Main Outcome Measure(s) Thrombin activatable fibrinolysis inhibitor, D-dimer, plasminogen activator inhibitor-1, and the thrombin generation test. Result(s) Thrombin generation lag-time was significantly shorter in women with PCOS compared with controls. The other hemostatic parameters were similar in both groups. Conclusion(s) Thrombin generation is faster in young and overweight women with PCOS, suggesting a greater risk of hypercoagulability.

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