Seasonal effects on vitamin D status influence outcomes of lifestyle intervention in overweight and obese women with polycystic ovary syndrome  

Oleh:

Thomson, Rebecca L. ; Spedding, Simon ; Brinkworth, Grant D. ; Noakes, Manny ; Buckley, Jonathan D.

Jenis: Article from Journal - ilmiah internasional
Dalam koleksi: Fertility and Sterility (keterangan: ada di ClinicalKey) vol. 99 no. 06 (May 2013), page 1779-1785.
Topik: 25-Hydroxyvitamin D; polycystic ovary syndrome; waist circumference; cholesterol; obesity

Ketersediaan

Perpustakaan FK Nomor Panggil: F02.K.2013.04 Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

Lihat Detail Induk

Isi artikel

Objective To investigate the effect of undertaking lifestyle interventions during periods of seasonal change on vitamin D status and health outcomes in overweight/obese women with polycystic ovary syndrome (PCOS). Design Retrospective, unplanned secondary analysis of two cohorts during different seasons. Setting Outpatient clinical research unit. Patient(s) Fifty overweight/obese women with PCOS. Intervention(s) Twenty-week lifestyle modification program (Clinical Trials registration no.: ACTRN12606000198527); one cohort started in winter and finished in summer, and one started in summer and finished in winter. Main Outcome Measure(s) 25-Hydroxyvitamin D (25OH-D), weight, waist circumference (WC), body composition, cardiovascular disease (CVD) risk factors, and menstrual cycle length. Result(s) Baseline 25OH-D levels were 27.6 ± 9.0 nmol/L. The winter cohort had lower 25OH-D levels at baseline, which increased over 20 weeks, whereas the summer cohort started with higher levels which decreased. Changes in 25OH-D were inversely correlated with changes in WC and cholesterol when controlling for baseline values, such that increases in 25OH-D were associated with greater reductions in WC and cholesterol. Conclusion(s) Obesity and CVD risk profiles improved in vitamin D–deficient women with PCOS after a 20-week lifestyle intervention during which vitamin D status improved with seasonal change. Clinical Trial Registration Number ACTRN12606000198527.

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