Falsely elevated serum antimullerian hormone level in a context of heterophilic interference  

Oleh:

Cappy, Helene ; Pigny, Pascal ; Leroy-Billiard, Maryse ; Dewailly, Didier ; Catteau-Jonard, Sophie

Jenis: Article from Journal - ilmiah internasional
Dalam koleksi: Fertility and Sterility (keterangan: ada di ClinicalKey) vol. 99 no. 06 (May 2013), page 1729-1732.
Topik: Antimullerian hormone; heterophile antibodies; immunoassay

Ketersediaan

Perpustakaan FK Nomor Panggil: F02.K.2013.04 Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

Lihat Detail Induk

Isi artikel

Objective To describe a case of falsely elevated serum antimüllerian hormone (AMH) level in an infertile 37-year-old woman with rheumatoid arthritis. Design Case report. Setting Lille University IVF center. Patient(s) A 37-year-old woman with rheumatoid arthritis demonstrating a high serum AMH level (74.5 ng/mL) and a low antral follicle count. Intervention(s) Assay with a Heterophilic Blocking Tube (HBT) to avoid heterophilic interference. Main Outcome Measure(s) Serum AMH level, ultrasound antral follicle count, hormonal assays on the 4th day of a spontaneous cycle. Result(s) The results of the infertility workup were as follows: serum AMH: 74.5 ng/mL (15-fold the upper limit of normal) (immunoassay: Immunotech); LH: 3.2 IU/L; FSH: 4.5 IU/L; E2: 27 pg/mL; PRL: 10 ng/mL. The antral follicle count (follicles from 2 to 9 mm) at ultrasound was 7 for both ovaries. Because there were discrepancies between the serum AMH level and the results of the infertility workup using the bioassays, we suspected a case of falsely elevated AMH level due to heterophilic interference. An HBT tube revealed a serum AMH level of 0.63 ng/mL. Conclusion(s) This case illustrates, for the first time, the possibility of a falsely high serum AMH level due to heterophilic interference.

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