Association of methionine synthase and thymidylate synthase genetic polymorphisms with idiopathic recurrent pregnancy loss  

Oleh:

Kim, Ji Hyang ; Jeon, Young Joo ; Lee, Bo Eun ; Kang, Hojeong ; Shin, Ji Eun

Jenis: Article from Journal - ilmiah internasional
Dalam koleksi: Fertility and Sterility (keterangan: ada di ClinicalKey) vol. 99 no. 06 (May 2013), page 1674-1680.
Topik: One-carbon metabolism; homocysteine; polymorphism; recurrent pregnancy loss

Ketersediaan

Perpustakaan FK Nomor Panggil: F02.K.2013.04 Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

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Isi artikel

Objective To investigate the association between one-carbon metabolism and recurrent pregnancy loss (RPL). One-carbon metabolism is important for maintaining pregnancy, and the enzymes codified by these genes are relevant to this metabolic pathway. Design Case-control study. Setting An urban university-based hospital in South Korea. Patient(s) A cohort of 353 RPL patients (3.09 ± 1.65 pregnancy losses) and 226 control subjects. Intervention(s) None. Main Outcome Measure(s) Genotyping was assessed by polymerase chain reaction–restriction fragment length polymorphism assay. We examined polymorphisms in four genes: methionine synthase (MTR); methionine synthase reductase (MTRR); methylenetetrahydrofolate dehydrogenase 1 (MTHFD1); and thymidylate synthase (TS). Result(s) The MTR 2756AA polymorphism was associated with RPL. Gene-gene interaction analysis revealed that the frequency of the MTR 2756A–TS 6-bp allele combination was significantly higher in RPL. Conclusion(s) Based on these results, we propose that the MTR 2756AA genotype and MTR 2756A–TS 6-bp allele combination are possible predisposing factors for RPL development in Korean women.

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