Formulation of Peperomia pellucida (L) Kunth Extract Tablet by Modified Filler  

Oleh:

Wijaya, Yunarto

Jenis: Article from Journal - ilmiah nasional
Dalam koleksi: Health Science Journal of Indonesia vol. 04 no. 01 (Jun. 2013), page 32-36.
Topik: Formulasi; Extract p. Pellucida; Optimal; Formulation; p. Pellucida extract; Optimize
Fulltext: H25 v4(1) jun13 p32,win.pdf (28.61KB)

Ketersediaan

Perpustakaan PKPM Nomor Panggil: H25.1 Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada	Lihat Detail Induk
Perpustakaan FK Nomor Panggil: H25.K Non-tandon: 1 (dapat dipinjam: 1) Tandon: tidak ada	Reserve Lihat Detail Induk

Isi artikel

Background: Peperomia pellucida has been widely used in traditional medicine. Recently, its existing forms are still conventional such as juice and infusum; therefore, it needs to be formulated more practically and in uniform weight such as tablet form. The objective of this research was to get the optimum formula of P. pellucida extract tablet. Methods: P. pellucida extract tablets were produced with variation of microcrystalline cellulose (MCC) PH 101 – lactose by wet granulation method in three formulas, formula I (100% MCC PH 101), II (lactose 100%), and III (MCC PH 101: lactose = 50%: 50%). Granules were evaluated their physical characteristics including their fl ow rate, water absorption and compactibility to obtain the optimum formula by using simplex lattice design and total response. The optimum formula was used to make tablet and tested its physical characteristics (uniformity weight, hardness, and friability and disintegration time). Results: Lactose signifi cantly infl uenced by its fl ow rate, whereas MCC PH 101 infl uenced the compactibility and water absorption. Based on the granules physical characteristics and their total responses, the formula combination of MCC PH 101 80% and lactose 20% was concluded to be the most optimum one for tablet fi ller. This optimum formula tablet had the best physical characteristics with weigth uniformity of 620.84 ± 1.04 mg, hardness of 8.54 ± 0.68 kg, friability of 0.26% ± 0.04 and disintegration time of 4.58 ± 0.17 minutes. Conclusion: The proportion MCC PH 101 80% and lactose of 20% obtained the best optimum formula and passed requirements of the tablet physical characteristics.

Opini Anda

Klik untuk menuliskan opini Anda tentang koleksi ini!

Kembali