Influence of Rifampicin on Nevirapine Plasma Concentration in HIV-TB Coinfected Patients  

Oleh:

Nafrialdi ; Nugroho, Agus W. ; Yunihastuti, Evy ; Wiria, Meta S.S.

Jenis: Article from Journal - ilmiah nasional - terakreditasi DIKTI
Dalam koleksi: Acta Medica Indonesiana vol. 44 no. 2 (Apr. 2012), page 135-139.
Topik: Rifampicin; nevirapine; HIV-TB coinfection; drug interaction.
Fulltext: Influence of Rifampicin on Nevirapine Plasma.pdf (1.24MB)

Ketersediaan

Perpustakaan FK Nomor Panggil: A02.K Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

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Isi artikel

Aim: to evaluate the influence of rifampicin on nevirapine plasma concentration in HIV-TB coinfected patients. Methods: this was a cross sectional study on 40 HIV patients (16 with HIV-TB coinfection, and 24 HIV without TB) conducted in HIV-AIDS study group (Pokdisus AIDS) of Cipto Mangunkusumo Hospital, Jakarta in October-November 2008. Those who had consumed both drugs for at least 2 weeks were recruited. Plasma nevirapine level was measured by using HPLC method, and the comparison between the two groups was done by unpaired t-test. Results: Nevirapine plasma level (mean+SD) in HIV patient was 7.5+2.2 ug/ml, while in HIV-TB patients it was 5.5+2.7 ug/ml (p=0.018). In most of patients receiving rifampicin, the plasma nevirapine concentration was still in therapeutic range. Conclusion: co-administration of rifampicin was associated with a significant decrease in nevirapin plasma concentration. However, this level was still in therapeutic range.

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